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KaliVir Immunotherapeutics

Our Company

About KaliVir

A clinical-stage company advancing a differentiated, multi-mechanistic oncolytic immunotherapy for cancers that resist checkpoint inhibitors.

Our story

Pioneering the next generation of oncolytic immunotherapies

$120M+
invested in the VET™ platform, including investment in predecessor Western Oncolytics and approximately $82M in non-dilutive partnership funding from Astellas Pharma and Roche

Founded in Pittsburgh, Pennsylvania, in 2019, KaliVir Immunotherapeutics was established to advance a new generation of oncolytic immunotherapies engineered to harness the immune system against cancer, including tumors that resist checkpoint inhibitors. The company builds on pioneering research in tumor immunology and viral engineering at the University of Pittsburgh, and on advances in oncolytic immunotherapy first made at its predecessor, Western Oncolytics.

That scientific foundation gave rise to KaliVir’s proprietary Vaccinia Enhanced Template (VET™) platform, which integrates multiple genetic modifications into the vaccinia backbone. VET™ is designed to overcome the limitations of earlier oncolytic approaches through enhanced tumor selectivity and targeting, flexibility for both intratumoral and intravenous delivery, and local expression of therapeutic payloads that activate antitumor immunity.

From its beginnings as an emerging biotechnology company backed by early investors, KaliVir has evolved into a clinical-stage immuno-oncology company. Our lead clinical candidate, VET3-TGI, is being evaluated in the Phase 1/1b STEALTH-001 study, and the VET™ platform has attracted global partnerships with Astellas Pharma and Roche.

Leadership

A seasoned executive team with R&D and immuno-oncology experience

Our team’s expertise spans vaccinia virus biology and immuno-oncology, oncolytic virus discovery and preclinical translation, Phase 1 through global Phase 3 programs, and start-ups and partnering. Members of our clinical and regulatory team have helped advance oncolytic immunotherapies from first-in-human studies through registrational development, including at CG Oncology.

Helena Chaye, J.D., Ph.D.
Chief Executive Officer
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Dr. Helena Chaye is Chief Executive Officer of KaliVir Immunotherapeutics and has over 25 years of experience in the biotechnology industry, with a sustained focus on the development of oncolytic immunotherapies. She has held senior leadership roles across corporate strategy, operations, business development, and intellectual property management, and has experience guiding organizations through scientific, regulatory, and corporate development milestones.

Prior to KaliVir, Dr. Chaye served as Chief Executive Officer of Western Oncolytics, following roles as Acting Chief Operating Officer and Chief Business Officer, where she supported corporate strategy, operational execution, and the advancement of clinical and preclinical programs. Earlier, she served as Chief Business Officer at SillaJen Biotherapeutics, where she was responsible for corporate and business development strategy, R&D planning, and intellectual property. She previously held senior roles at Jennerex Biotherapeutics and MediGene.

Dr. Chaye holds a B.S. in Biochemistry and a Ph.D. in Genetics from the University of British Columbia and a J.D. from Dalhousie University.

Stephen H. Thorne, Ph.D.
Chief Scientific Officer & Co-Founder
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Dr. Stephen Thorne is Chief Scientific Officer and co-founder of KaliVir Immunotherapeutics and has played a foundational role in the field of oncolytic immunotherapy. His work has contributed to the scientific underpinnings of multiple oncolytic immunotherapy platforms and informed translational and clinical development strategies.

Dr. Thorne has co-founded several biotechnology companies focused on oncolytic immunotherapies, including Western Oncolytics, Duo Oncology, BioEclipse Therapeutics, and Jennerex. He previously served as Associate Professor of Cell Biology and Immunology at the University of Pittsburgh.

Dr. Thorne has authored more than 100 peer-reviewed scientific publications, including articles in journals such as Nature Medicine, Cancer Cell, Clinical Cancer Research, and Molecular Therapy. He completed postdoctoral training at Cancer Research UK, the University of Surrey, and Stanford University. Dr. Thorne received his B.A. from the University of Oxford and his Ph.D. from Imperial College London.

James M. Burke, M.D.
Chief Medical Officer
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Dr. James Burke is Chief Medical Officer of KaliVir Immunotherapeutics and has more than 20 years of experience leading global clinical development programs in gene therapy and immuno-oncology, with a particular focus on oncolytic immunotherapies.

Most recently, Dr. Burke served as Chief Medical Officer at CG Oncology, where he led the preclinical, translational, and clinical development of cretostimogene grenadenorepvec (CG0070) from first-in-human Phase 1 studies through pivotal Phase 3 trials and supported the Company’s subsequent NASDAQ initial public offering. His experience includes clinical strategy, trial execution, regulatory engagement, and preparation for registrational pathways. In addition to clinical development, Dr. Burke has supported medical affairs activities and business development efforts within immuno-oncology and oncolytic immunotherapy therapeutics areas.

Dr. Burke holds a B.S. in Biochemistry and Cell Biology from the University of California, San Diego, an M.D. from Georgetown University, and completed fellowship training in hematology and oncology at the University of California, San Francisco.

Schond L. Greenway, MBA
Chief Financial Officer
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Schond Greenway is Chief Financial Officer of KaliVir Immunotherapeutics and has more than 25 years of experience in corporate finance and capital markets leadership across emerging and public biotechnology companies. In addition to his capital markets expertise, Mr. Greenway has built and overseen financial/accounting and IT functions, and supported enterprise risk management, while aligning capital strategy with clinical and corporate inflection points.

Prior to KaliVir, Mr. Greenway served as CFO of Definium (formerly Mind Medicine), Avalo Therapeutics, and held senior finance and strategy leadership roles at Mesoblast Ltd, Halozyme Therapeutics, and DURECT Corporation (acquired by Bausch Health). He began his career in investment banking at Morgan Stanley and later served as a Vice President, healthcare desk research analyst at Barclays Capital.

Across his investment banking and operating roles, Mr. Greenway has advised on transactions totaling more than $30 billion and has secured over $1.5 billion in growth equity, private capital, and strategic R&D funding for biopharmaceutical companies.

Mr. Greenway holds a B.S. in Computer Information Systems from Florida A&M University and an MBA from the Darden School of Business at the University of Virginia.

Adina Pelusio, M.S., M.P.H.
Chief Development Officer
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Adina Pelusio is Chief Development Officer at KaliVir Immunotherapeutics and has experience leading global clinical development programs across oncolytic immunotherapies, cell therapies, cancer vaccines, and other complex biologic products requiring heightened regulatory oversight.

Prior to KaliVir, Ms. Pelusio served as Senior Vice President of Clinical Operations at Turnstone Biologics, where she led the global execution of the company’s clinical development strategy across cell therapy and oncolytic immunotherapy programs. She previously held senior clinical operations roles at SillaJen Biotherapeutics and Jennerex Biotherapeutics.

Ms. Pelusio holds a B.S. from the University of Miami, an M.S. in Medical Microbiology with a focus on virology and immunology from the University of Florida, and an M.P.H. in Epidemiology and Biostatistics from Harvard University.

Ursula Fritsch, PharmD
Chief Regulatory Officer
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Dr. Ursula Fritsch is Chief Regulatory Officer at KaliVir Immunotherapeutics and has more than 30 years of experience in global regulatory affairs and quality assurance across all phases of drug development.

Dr. Fritsch has led regulatory strategy from pre-IND through NDA and BLA submission and commercialization and has overseen regulatory submissions for over [X] products. She has experience directing regulatory programs for multiple oncolytic immunotherapy companies, including Onyx Pharmaceuticals, Jennerex Biotherapeutics, SillaJen, and CG Oncology, where she supported FDA alignment on pivotal and registrational study designs.

Her prior roles include Vice President of Global Regulatory Affairs and Compliance at Anthera Pharmaceuticals and senior regulatory leadership positions at Peninsula Pharmaceuticals and Genentech.

Dr. Fritsch holds a B.A. from the University of Nebraska and a PharmD from Creighton University.

Paul Youm, J.D.
Executive Vice President, Business Development and Corporate Affairs
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Paul Youm is Executive Vice President of Business Development and Corporate Affairs at KaliVir Immunotherapeutics and has experience supporting strategic transactions, partnerships, and alliance management within the life sciences sector. Mr. Youm has experience working with business development teams on the licensing of technology, from early-stage partnership discussions through contract negotiation, alliance kickoff, and ongoing operational execution.

Prior to joining KaliVir, Mr. Youm held senior roles including President of YNY Associates, Executive Director of Business Development at ROKIT Healthcare, and In-House Counsel and Business Development Director at SillaJen Biotherapeutics. He has been involved in venture and pre-IPO financings, IPO diligence, licensing and collaboration agreements, alliance management, and corporate governance.

Mr. Youm is licensed with the Korean Bar Association and holds a B.S. in Biomedical Engineering from Duke University and a Master of Laws degree from Sogang University School of Law in Seoul.

Board of Directors

Helena Chaye, J.D., Ph.D.
Chief Executive Officer
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Dr. Helena Chaye is Chief Executive Officer of KaliVir Immunotherapeutics and has over 25 years of experience in the biotechnology industry, with a sustained focus on the development of oncolytic immunotherapies. She has held senior leadership roles across corporate strategy, operations, business development, and intellectual property management, and has experience guiding organizations through scientific, regulatory, and corporate development milestones.

Prior to KaliVir, Dr. Chaye served as Chief Executive Officer of Western Oncolytics, following roles as Acting Chief Operating Officer and Chief Business Officer, where she supported corporate strategy, operational execution, and the advancement of clinical and preclinical programs. Earlier, she served as Chief Business Officer at SillaJen Biotherapeutics, where she was responsible for corporate and business development strategy, R&D planning, and intellectual property. She previously held senior roles at Jennerex Biotherapeutics and MediGene.

Dr. Chaye holds a B.S. in Biochemistry and a Ph.D. in Genetics from the University of British Columbia and a J.D. from Dalhousie University.

Stephen H. Thorne, Ph.D.
Co-Founder and Chief Scientific Officer
Read bio

Dr. Stephen Thorne is Chief Scientific Officer and co-founder of KaliVir Immunotherapeutics and has played a foundational role in the field of oncolytic immunotherapy. His work has contributed to the scientific underpinnings of multiple oncolytic immunotherapy platforms and informed translational and clinical development strategies.

Dr. Thorne has co-founded several biotechnology companies focused on oncolytic immunotherapies, including Western Oncolytics, Duo Oncology, BioEclipse Therapeutics, and Jennerex. He previously served as Associate Professor of Cell Biology and Immunology at the University of Pittsburgh.

Dr. Thorne has authored more than 100 peer-reviewed scientific publications, including articles in journals such as Nature Medicine, Cancer Cell, Clinical Cancer Research, and Molecular Therapy. He completed postdoctoral training at Cancer Research UK, the University of Surrey, and Stanford University. Dr. Thorne received his B.A. from the University of Oxford and his Ph.D. from Imperial College London.

Tom Leonard
Director · Technology entrepreneur
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Tom Leonard is a serial entrepreneur who has founded and led several technology companies. He co-founded and led Clear Voice Research, Red Rocket Solutions, Encore Development and TML Systems, and previously served as Chief Operating Officer and Chief Information Officer of DMEautomotive. He has served on the boards of Western Oncolytics, Caretta Data and DMEautomotive.

Earlier in his career, Mr. Leonard was a General Manager at Symantec and a Software Architect at Harris Corporation. He holds a B.S. and an M.S. in Computer Science from Florida State University.

Jon Wigginton, M.D.
Director · President of R&D, Bright Peak Therapeutics
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Dr. Jon Wigginton has more than 25 years of experience in oncology and immuno-oncology drug development. He is President of Research and Development at Bright Peak Therapeutics. He previously served as Chief Medical Officer and Senior Vice President of Clinical Development at MacroGenics and as Chief Medical Officer of Cullinan Oncology, and founded Bethesda Biomedical Consulting.

Previously, Dr. Wigginton was Therapeutic Area Head of Immuno-Oncology, Early Clinical Research at Bristol-Myers Squibb, where he led early clinical development of the company’s immuno-oncology portfolio, including anti-PD-1, anti-PD-L1 and anti-CTLA-4/anti-PD-1 combinations. Before that, he was Director of Clinical Oncology at Merck Research Laboratories and held several positions at the National Cancer Institute’s Center for Cancer Research, including Head of the Investigational Biologics Section in the Pediatric Oncology Branch.

Dr. Wigginton is a past President of the Society for Immunotherapy of Cancer (SITC). He received a B.S. in Biology and an M.D. from the University of Michigan.

Kurt Rote, M.B.A.
Director · Co-Founder, Western Oncolytics
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Kurt Rote co-founded Western Oncolytics, KaliVir’s predecessor, and led the company through technology licensing from the University of Pittsburgh, seed and Series A fundraising, and its partnership with Pfizer.

He previously served as Head of Product Development and Marketing at Biognosys AG and held strategy and business development roles at Holcim US. Mr. Rote holds an M.B.A. from IMD (International Institute for Management Development) in Switzerland and a B.S.E. from Duke University.

Woo Young Kim
Director · Company K Partners
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Woo Young Kim joined KaliVir’s Board of Directors in August 2026 and represents Company K Partners, which led KaliVir’s Series A extension financing.

Kwang Ha Jung
Director · SV Investment
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Kwang Ha Jung joined KaliVir’s Board of Directors in August 2026 and represents SV Investment, a participant in KaliVir’s Series A extension financing.

JP Hong
Director · Flexus Partners
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JP Hong joined KaliVir’s Board of Directors in August 2026 and represents Flexus Partners, a participant in KaliVir’s Series A extension financing.

Advisors

Scientific Advisory Board

Tullia Bruno, Ph.D.
Assistant Professor, Department of Immunology, University of Pittsburgh
Greg Delgoffe, Ph.D.
Professor, Department of Immunology; Director, TME Center, University of Pittsburgh
Michael Lotze, M.D.
Professor of Surgery, Immunology, and Bioengineering, University of Pittsburgh School of Medicine
Jon Wigginton, M.D.
President of R&D, Bright Peak Therapeutics

Clinical Advisory Board

Mitesh Borad, M.D.
Professor of Medicine, Mayo Clinic
Roger Li, M.D.
Genitourinary Oncology, Moffitt Cancer Center
Jorge Nieva, M.D.
Associate Professor of Clinical Medicine, University of Southern California
Jonathan Rosenberg, M.D.
Chief, Genitourinary Oncology, Memorial Sloan Kettering Cancer Center
Dmitriy Zamarin, M.D., Ph.D.
Professor and Section Head, Gynecologic Medical Oncology, Icahn School of Medicine at Mount Sinai

Partnering

Powering the next generation of immunotherapy

We are dedicated to advancing the frontier of cancer care and pioneering the next generation of innovative oncolytic immunotherapies engineered to selectively target tumors, converting “cold” environments into “hot,” immune-receptive zones. By leveraging our dual mechanisms of direct cellular lysis and systemic immune activation, we create a potent foundation for synergistic combinations with checkpoint inhibitors and potentially other oncology therapeutics.

Versatile delivery for comprehensive care

Our oncolytic platform is engineered for both intratumoral and intravenous delivery, providing the flexibility to target tumors directly or reach metastases systemically.

Strategic partnering interests

We invite strategic partners to collaborate on these next-generation modalities to overcome treatment resistance and redefine the standard of care for patients with hard-to-treat cancers. We are actively seeking collaborations that amplify the clinical impact of our VET™ platform and accelerate the delivery of life-changing therapies to patients. Our primary areas of interest include:

01

Combination therapy trials

Identifying synergies with established and emerging standards of care, including PD-1/PD-L1 inhibitors and CTLA-4 blockers.

02

Pipeline expansion and payloads

Co-developing next-generation assets by integrating novel therapeutic payloads, such as cytokines or bispecific antibodies, into our proprietary delivery vehicles.

03

Joint clinical development

Establishing co-development agreements for clinical assets.

04

Out-licensing

Global and regional collaborations that leverage a partner’s clinical and commercial expertise to maximize the reach and impact of the therapeutic assets in our pipeline.

Current collaborations

Astellas Pharma

We have partnered with Astellas Pharma under an updated licensing agreement for VET2-L2 (ASP1012), a systemically delivered oncolytic immunotherapy designed for patients with advanced or metastatic solid tumors. The program continues to advance under a revised development arrangement pursuant to an amendment to the original licensing agreement.

Roche

Roche supplies atezolizumab (TECENTRIQ®) for the STEALTH-001 combination cohorts evaluating VET3-TGI with checkpoint inhibition.

Our collaboration process

Whether you are interested in a specific clinical-stage asset or a broader platform collaboration, we invite you to start the conversation. For more information or inquiries on collaborations and partnerships, please send an inquiry below.

Send a partnering inquiry

Investors

Company K Partners
Nextrans
SV Investment
Flexus Partners
Premier Partners
QUAD
Hana Financial Group

Careers

Join a focused team working for patients who’ve run out of options

Pipetting samples in the laboratory

Contact

Headquarters

240 Alpha Drive
Pittsburgh, PA 15238
412-435-6730

Business development

bd@kalivir.com

Investors & media

ir@kalivir.com

Medical information

medinfo@kalivir.com

General inquiries

info@kalivir.com
This site contains information about VET3-TGI, an investigational agent that has not been reviewed or approved by the U.S. Food and Drug Administration or any other regulatory authority. Its safety and efficacy have not been established.